A trio of Betazoids cause chaos on the U.S.S. Cerritos.

Tawny Newsome (Lt. Beckett Mariner)
Jack Quaid (Lt. Brad Boimler)
Noël Wells (Lt. D'Vana Tendi)
Eugene Cordero (Lt. Sam Rutherford)
Dawnn Lewis (Captain Carol Freeman)
Jerry O'Connell (Commander Jack Ransom)
Fred Tatasciore (Lieutenant Shaxs)
Gillian Vigman (Dr. T'Ana)

Gideon Adlon (Ensign Haubold)
Rachel Dratch (Dolorex)
Janelle James (Katrot)
Wendie Malick (Cathiw)
Jessica McKenna (Ensign Barnes)
Gabrielle Ruiz (Lieutenant T'Lyn)
Paul Scheer (Lt. Cmdr. Andy Billups)
Carl Tart (Lieutenant Kayshon)
Paul F. Tompkins (Dr. Migleemo)

• The episode references the Betazoid syndrome Zanthi Fever, first seen in the DS9 episode "Fascination", but it turns out T'Lyn has Bendii Syndrome, which typically affects older Vulcans ("Sarek").
  
• Dolorex, Katrot, and Cathiw are part of the Betazoid Intelligence Agency (BIA) and are secretly investigating the ship that has been destroying the ships since the season opener "Twovix".