A devastating revelation about Jack alters the course of Picard’s life forever — and uncovers a truth that threatens every soul in the Federation. The final battle begins as Picard and his crew race to save the galaxy from annihilation — but not without a gut-wrenching cost.

Patrick Stewart (Admiral Jean-Luc Picard)
Jeri Ryan (Commander Seven of Nine)
Michelle Hurd (Commander Raffi Musiker)
Ed Speleers (Jack Crusher)

Brent Spiner (Data)
LeVar Burton (Commodore Geordi La Forge)
Michael Dorn (Captain Worf)
Jonathan Frakes (Captain William T. Riker)
Gates McFadden (Dr. Beverly Crusher)
Marina Sirtis (Deanna Troi)
Alice Krige (The voice of the Borg Queen)

Todd Stashwick (Captain Liam Shaw)
Ashlei Sharpe Chestnut (Ensign Sidney La Forge)
Elizabeth Dennehy (Admiral Elizabeth Shelby)

Mica Burton (Ensign Alandra La Forge)
Joseph Lee (Lt. Matthew Arliss Mura)
Jin Maley (Ensign Kova Rin Esmar)
Nolan North (Captain Benbassat)
Majel Barrett (U.S.S. Enterprise Computer)
Amy Earhart (U.S.S. Titan Computer)
Grace Gregory (Security Officer)
Jane Edwina Seymour (Borg Queen Body Double)

• When Troi helps Jack open the red door in his mind, she sees a Borg cube and hears them speak "We are Borg".
  
• It is revealed Picard's diagnosis of irumodic syndrome was incorrect. It was a biological alteration by the Borg, which is how he was still able to hear them in Star Trek: First Contact. The changelings embedded the DNA code into the fleet transporter systems, which infected anyone who used the transporter allowing them to be assimilated remotely when the Borg sent a fleet-wide signal. The DNA modification only worked in indviduals whose front cortex was still developing, around the age of 25 in humans.
  
• Jack escapes custody and steals a shuttle. When he finds the Borg, he beams aboard the cube and the Borg inject a cable into his spine. This allows the Borg to transmit the activation signal.
  
• Vōx is Latin for voice, and is the new name the Borg Queen gives Jack. (It would typically be spelled with a macron over the ō, but the title card spells it with a tilde.)
  
• The U.S.S. Enterprise NCC-1701-F (commanded by Admiral Shelby) is launched on Frontier Day, the 250th anniversary of the launch of the Enterprise NX-01.
  
• In need of a ship that is not linked to the rest of the fleet, La Forge takes the crew to the Fleet Museum, where he reveals the restored Galaxy-class U.S.S. Enterprise NCC-1071-D. It was rebuilt with what was left of the saucer section retrieved from Veridian III and the engines from the U.S.S. Syracuse.
  
• After revealing the U.S.S. Enterprise-D, Geordi muses they were unable to use the U.S.S. Enterprise-E, and everyone looks to Worf, who insists that it was not his fault. In the tie-in novel The Last Best Hope by Una McCormack, Worf has been promoted to captain of the U.S.S. Enterprise-E, though this is not confirmed as canon in the series. When they board the U.S.S. Enterprise-D, Worf notes that he prefers the weapons systems on the U.S.S. Enterprise-E.
  
• Captain Shaw is killed by the newly assimilated Borg on the U.S.S. Titan, and Seven and Raffi are left behind as they try to help him.
  
• Elizabeth Dennehy reprises her role as Shelby, first seen in "The Best Of Both Worlds". Her first name is confirmed as Elizabeth here.
  
• Alice Krige returns as the voice of the Borg Queen, having previously played the physical role in Star Trek: First Contact and the Voyager finale, "Endgame".