A final confrontation on the synthetics' homeworld, Coppelius, pits Picard and his team against the Romulans, as well as the synths who seek to safeguard their existence at all costs.

Patrick Stewart (Jean-Luc Picard)
Alison Pill (Dr. Agnes Jurati)
Isa Briones (Dr. Soji Asha)
Evan Evagora (Elnor)
Michelle Hurd (Raffi Musiker)
Santiago Cabrera (Cristóbal Rios)
Harry Treadaway (Narek)

Jeri Ryan (Seven of Nine)
Jonathan Frakes (William Riker)
Brent Spiner (Dr. Altan Inigo Soong)

Peyton List (Lt. Narissa Rizzo)
Tamlyn Tomita (Commodore Oh)

Kay Bess (La Sirena computer)
Brian DeRozan (Romulan Officer)
Matt Perfetuo (Rune)
Mike Perfetuo (Codex)
Jade Ramsey (Arcana)
Nikita Ramsey (Saga)

• First Season Finale.
  
• At the last minute, Will Riker arrives commanding the U.S.S. Zheng He NCC-86505, Inquiry-class, along with a fleet of Federation starships. (Because the COVID lockdown happened during post-production, the fleet consists solely of multiple Inquiry-class starships.)
  
• When Picard succumbs to his condition, Agnes, Soong, and Soji transfer his mind into the golem.
  
• During the procedure, Picard interacts with a simulation of Commander Data. His consciousness was created by Bruce Maddox using neurons from Data's memory transfer into B4. Data requests Picard shut down his consciousness.
  
• With the synthetic ban lifted, Soji and Picard leave Coppelius on La Sirena, along with Rios, Jurati, Elnor, Raffi and Seven.