| Season | Episode | Airdate | Episode Title | Story Line |
| 07.01 | 140 | 09/16/2004 | FYI: I Hurt, Too | Jack and Jennifer Lopez return from her summer tour, and Karen recruits Jack to help her get J-Lo to listen to her newly written ballad. Meanwhile, Grace takes out her frustrations over cheating husband Leo on Will. |
| 07.02 | 141 | 09/23/2004 | Back Up, Dancer | Jack auditions as a backup dancer for Janet Jackson. Meanwhile, Grace comes between Will and Vince. |
| 07.03 | 142 | 09/30/2004 | One Gay at a Time | Free food lures Grace to AA, where she links up again with wacky Val; a new gay TV network relishes Jack's earthy ideas, like a nude variation of "Jeopardy." |
| 07.04 | 143 | 10/07/2004 | Company | Will and Grace invite a new neighbor over for dinner. Meanwhile, Jack feels he can't relate to his new co-workers after they mock him about his Cher doll. |
| 07.05 | 144 | 10/14/2004 | Key Party | Vince has the perfect gift for Will's birthday -- until Grace convinces him otherwise. Meanwhile, Karen is depressed because Will's birthday coincides with her late husband Stan's birthday. |
| 07.06 | 145 | 10/21/2004 | The Newlydreads | Karen takes over when Grace can't handle a newlywed couple. Will convinces Jack to aid a local gay-bookstore owner to save his store from closing. |
| 07.07 | 146 | 11/04/2004 | Will & Grace & Vince & Nadine | Will and Grace invite Vince and his straight female friend, Nadine, over for dinner and her sweetness belies a deep-rooted jealousy. Meanwhile, Karen's stint as Jack's assistant at Out TV proves disastrous. |
| 07.08 | 147 | 11/11/2004 | Saving Grace, Again (Part 1) | Memories of Leo haunt Grace as their wedding anniversary nears and she readies to get back in the dating game. Meanwhile, Karen and Jack fix each other up on dates, which, of course, turn out disastrously. |
| 07.09 | 148 | 11/18/2004 | Saving Grace, Again (Part 2) | Will and Grace go on a road trip for Grace's getaway weekend, while Jack signs up a has-been commercial star for the Out TV spokesman. |
| 07.10 | 149 | 11/25/2004 | Queens for a Day | A chaotic Thanksgiving with Vince's folks finds Grace attracted to a young hunk, Jack privy to a sex secret that could tear the family apart, and Will cooking and trying to keep the peace. |
| 07.11 | 150 | 12/09/2004 | Christmas Break | Grace attends a holiday party at Will's mother's home and accidentally breaks a treasured Lladro figurine. Meanwhile, Karen's reunited with her stepdaughter, whose connivances are known to Jack. |
| 07.12 | 151 | 01/06/2005 | Board Games | A spiteful magnate seeks to bankrupt Karen over a high-school affront that scarred his psyche. Meanwhile, Grace and Jack run into Vince while playing hooky from work. |
| 07.13 | 152 | 01/13/2005 | Partners | Will's shrewd boss hosts a posh party to size up associates who are anxious for a full partnership in the firm. At the fete, the competition turns testy, and Grace winds up schmoozing with the boss's spouse. |
| 07.14 | 153 | 02/03/2005 | Bully Woolley | Using an alias, Scott Woolley hires Grace to design his new restaurant under the condition Grace fires Karen. Meanwhile, Jack takes Will out to the club to get his mind off Vince, but ends up ditching him. |
| 07.15 | 154 | 02/10/2005 | Dance Cards and Greeting Cards | Grace meets a hunky greeting card writer on Valentine's day as Karen's former nemesis Scott Woolley tries to win her heart by showering her with gifts. |
| 07.16 | 155 | 02/17/2005 | The Birds and the Bees | Grace has a hot date with a new beau, and an uncomfortable Will is talked into coming along so Grace doesn't get out of control. Meanwhile, Jack has the hots for nerdy bird-watcher Aaron. |
| 07.17 | 156 | 02/24/2005 | The Fabulous Baker Boy | A pastry chef frosts Karen, who wants the fellow fired by Will. Trouble is, he's attracted to the guy and his concoctions. Also, Grace's new beau is humbled by Jack, who, in turn, gets a dressing-down from Grace. |
| 07.18 | 157 | 03/17/2005 | Sour Balls | Will and Jack invest in a house at a "big, hot, gay getaway" in upstate New York. Meanwhile, Ellen asks Grace to babysit her three children, but changes her mind when she finds out Will is out of town. |
| 07.19 | 158 | 04/21/2005 | The Blonde Leading the Blind | Noted shrink Dr. Georgia Keller gives short shrift to Will and full attention to Grace, an "interesting" case study for the therapist's new book. Meanwhile, eyeglasses redefine reality for Karen. |
| 07.20 | 159 | 05/05/2005 | It's a Dad, Dad, Dad, Dad World | Jack secretly sets Will up for his new show on OutTV, "Pink'd". Grace and Karen go golfing with Grace's father and his buddy. |
| 07.21 | 160 | 05/10/2005 | From Queer to Eternity | Grace has a "near death" experience while shopping and decides to have Will draw up her will. Meanwhile, Jack discovers that someone is using the "McFarland Method" to teach acting classes. |
| 07.22 | 161 | 05/19/2005 | Friends with Benefits | Having quit his job at the law firm, Will turns to a career in writing. Meanwhile, Tom, an old flame from college, returns to ask Grace to design a hotel while Jack struggles to produce his latest show for OutTV; Karen is forced to apologize to Beverley. |
| 07.23 | 162 | 05/19/2005 | Kiss and Tell | Will becomes suspicious of his new boss and he discovers a startling secret about an old friend. Meanwhile, Grace quits the hotel design job when Tom can no longer hide his feelings; Jack is promoted to host of his own talk show with Karen as co-host. |